Kyogo Nagashima

Kyogo Nagashima

PhD Chemistry Student

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portfolio

publications

Temperature-dependent influence of FliA overexpression on PHL628 E. coli biofilm growth and composition

Published in Frontiers in Cellular and Infection Microbiology, 2021

It was demonstrated by Prof. Jiajia Ma’s group at Shanghai Tong University that an arene reduction reaction by hydrogen atom transfer enabled by energy transfer catalysis allows for a higher functional group tolerance. My goal was to support the hypothesis that the chemoselectivity of the reaction was dictated by triplet energies rather than reduction potentials in contrast to conventional reduction reactions. I was able to accomplish this through calculations of triplet energies and dexter energy transfers from an iridium-based photosensitizer, showing that a photocatalytic pathway prevents the functional groups from getting activated while allowing the hydrogen atom transfer to take place. In addition, I was able to propose a mechanism for this photocatalytic hydrogen atom transfer reaction through various Gibbs free energy and minimum energy crossing point calculations. Specifically, I calculated the energy barriers for all theoretically possible 48 reaction pathways, allowing me to elucidate the structural configurations that allow for a smooth hydrogen atom transfer reaction. This research paper in which I am the first author along with the principal experimentalist is published in Angewandte Chemie.

Recommended citation: Buck, L.D. ‡, Paladino, M.M. ‡, Nagashima, K., Holtzman, J.S., Brezel, E.R., Urso, S.J., Ryno, L.M. Temperature-dependent influence of FliA overexpression on PHL628 E. coli biofilm growth and composition. Frontiers in Cellular and Infection Microbiology, 2021, 11, 775270. DOI: 10.3389/fcimb.2021.775270
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Arene Reduction by Energy Transfer Catalysis Enabled Hydrogen Atom Transfer: Advancing the Chemoselectivity

Published in Angewandte Chemie International Edition, 2023

This paper is about the number 1. The number 2 is left for future work.

Recommended citation: Liu, D.‡, Nagashima, K.‡, Liang, H., Yue, X., Chu, Y., Chen, S., Ma, J. Arene Reduction by Energy Transfer Catalysis Enabled Hydrogen Atom Transfer: Advancing the Chemoselectivity. Angew. Chem., Int. Ed, 2023. DOI: 10.1002/anie.202312203
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talks

teaching

Tutor for Introductory Physics

1st year undergraduate course, Oberlin College, Physics, 2022

Responsible for helping students understand concepts and apply them to problems.

Tutor for General Chemistry

1st year undergraduate course, Oberlin College, Chemistry, 2023

Responsible for helping students understand concepts and apply them to problems.

Grader for Quantum Chemistry

3~4th year undergraduate course, Oberlin College, Chemistry, 2024

Responsible for grading weekly problem sets for Quantum chemistry class (Phys. Chem. II).

Tutor for General Chemistry II

1st year undergraduate course, Oberlin College, Chemistry, 2024

Responsible for helping students understand concepts and apply them to problems.